| ncRNA name | hsa-miR-21 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | normal retinal tissues and RB samples; RB cell line HXO-RB44 |
| Methods | transfection, qRT-PCR, flow cytometry, microarray |
| Expression pattern | up-regulated |
| Functional description | miR-21 was highly overexpressed in HXO-RB44 cells and Rb tissue specimens compared with normal human retinal tissues. We found that t-anti-miR-21 led to a significant inhibition of retinoblastoma cell proliferation, migration and colony formation in vitro, with a similar effect to anti-miR-21. |
| PubMed ID | 24607444 |
| Year | 2014 |
| Title | Seed-targeting anti-miR-21 inhibiting malignant progression of retinoblastoma and analysis of their phosphorylation signaling pathways. |
| Drug-related ncRNA | NO |
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